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T8581 |
Flecainide hydrochloride
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Others
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Flecainide is a medication used to prevent and treat abnormally fast heart rates. This includes ventricular and supraventricular tachycardias. |
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T16347 |
NS3623
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Potassium Channel
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NS3623 is an activator of human ether-a-go-go-related gene potassium channels. NS3623 has a dual mode of action, being an inhibitor of hERG1 channels. NS3623 activates the IKr and Ito currents and has an antiarrhythmic e... |
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T16348 |
NS5806
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NS-5806 |
Potassium Channel
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NS5806 is an effective potassium current activator. NS5806 slows KV4.3 and KV4.2 current decay in channel complexes containing KChIP2. NS5806 enhances KV4.3/KChIP2 peak current amplitudes (EC50: 5.3 μM). |
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T15286 |
Flindokalner
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BMS-204352 |
Potassium Channel
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Flindokalner (BMS-204352) is a potassium channel modulator and a positive modulator of all neuronal Kv7 channel subtypes expressed in HEK293 cells. Flindokalner is a large conductance calcium-activated K channel (BKca) p... |
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T1434 |
Clarithromycin
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A-56268 |
P450
,
ribosome
,
MRP
,
Antibacterial
,
Antibiotic
,
Autophagy
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Clarithromycin (A-56268) is a Macrolide Antimicrobial. The mechanism of action of clarithromycin is as a Cytochrome P450 3A4 Inhibitor, and Cytochrome P450 3A Inhibitor, and P-Glycoprotein Inhibitor. The chemical classif... |
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T7775 |
A2764 dihydrochloride
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Potassium Channel
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A2764 dihydrochloride is a highly selective inhibitor of TRESK. |
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T6541 |
Ibutilide Fumarate
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Corvert Fumarate,U70226E |
Calcium Channel
,
Sodium Channel
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Ibutilide Fumarate (U70226E) is the fumarate salt form of ibutilide, a class III antiarrhythmic agent. Ibutilide exerts its effect by activating a slow, inward, predominately sodium current rather than by blocking outwar... |
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T15758 |
Linopirdine
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DuP 996 |
Potassium Channel
,
TRP/TRPV Channel
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Linopirdine (DuP 996) is a TRPV1 agonist. Linopirdine is an orally active and selective M-type K+ current (IM; Kv7; KCNQ Channels) inhibitor (IC50: 2.4 μM). Linopirdine is a cognitive enhancer. It acts by stimulating rel... |
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T9009 |
ICA-105574
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ICA,3-nitro-N-[4-phenoxyphenyl]-benzamide |
HER
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ICA-105574 (ICA) is an activator of hERG that binds to the channel to remove inactivation, thus increasing peak current amplitude and shortening the action potential. It also modulates activation kinetics of the channel. |
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T3574 |
Sematilide hydrochloride
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CK-1752A,CK-1752,Sematilide HCl |
Potassium Channel
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Sematilide hydrochloride (CK-1752) is a class III antiarrhythmic. It is a selectively delayed rectifier K+ current (IKr) channel blocker. It inhibits rapidly activating Ik in guinea pig atrial myocytes, resulting in the ... |
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T22745 |
DPO-1
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Potassium Channel
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DPO-1 is a blocker of IKur ultrarapid delayed rectifier potassium current and KV1.5 channels |
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T5585 |
AM-92016 hydrochloride
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Potassium Channel
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AM-92016 is a specific blocker of rectifier potassium current. AM-92016 delays rectifier potassium channel and repolarizes the membrane thereby restricting the duration of the nerve impulse. |
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T7505 |
Azimilide Dihydrochloride
|
NE-10064 Dihydrochloride |
Potassium Channel
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Azimilide Dihydrochloride (NE-10064 Dihydrochloride), a novel class III antiarrhythmic agent, blocks both the slowly activating (IKs) and rapidly activating (IKr) components of the delayed rectifier potassium current |
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T27205 |
DPI 201-106
|
DPI-201-106 |
Sodium Channel
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DPI-201-106 is a cardioselective inhibitor of the TTX-resistant h1 Na channel inactivation. DPI-201-106 inhibits the L-type calcium current, and inward and delayed rectifier potassium currents. |
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T6476 |
Dofetilide
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UK 68789,UK-68798,Tikosyn |
Potassium Channel
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Dofetilide (UK 68789) is a sulfonamide class III antiarrhythmic agent and potassium channel blocker. Dofetilide selectively blocks cardiac ion channels of the rapid component of the delayed rectifier potassium current Ik... |
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T5336L |
Zacopride
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Racemic zacopride |
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Zacopride is a selective agonist of inward rectifier potassium current (I K1) channel, inhibiting ventricular arrhythmias without affecting atrial arrhythmias. |
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T69428 |
S9947
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|
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S9947 is a Kv1.5/IKur channel blocker, suppressing both cloned (Kv1.5) and native (IKur) cardiac potassium current. |
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T70194 |
AM92016
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|
|
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AM92016 is a specific blocker of the time dependent delayed rectifier potassium current. AM92016 does not show any β-adrenoceptor blocking activity. |
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T14189 |
Almokalant
|
H 234/09 |
Potassium Channel
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Almokalant is a class III antiarrhythmic drug, acts as a potassium channel blocker. And it inhibits a specific component (Ikr) of the time-dependent delayed rectifier K+ current. |
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T15460 |
Halofantrine hydrochloride
|
WR-171669,SKF-102886 |
Others
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Halofantrine hydrochloride is a blocker of delayed rectifier potassium current. Halofantrine hydrochloride also via the inhibition of the human-ether-a-go-go-related gene (HERG) channel and a potent antimalarial agent. |
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T61685 |
Ibutilide
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|
|
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Ibutilide (U70226E free base) is a potent antiarrhythmic compound that extends the action potential duration. It effectively blocks the rapidly activating delayed rectifier potassium current (I Kr ) in AT-1 cells [1]. |
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T80980 |
Tityustoxin-Kα
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TsTx-Kα |
|
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Tityustoxin-Kα (TsTx-Kα) acts as an inhibitor of potassium voltage-gated channels, exhibiting a dose-dependent blockade of the sustained outward current in cultured hippocampal neurons [1]. |
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T36215 |
17R(18S)-EpETE
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|
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17R(18S)-EpETE is an oxylipin and a cytochrome P450 metabolite of eicosapentaenoic acid .1,217R(18S)-EpETE is an activator of large-conductance calcium-activated potassium (BKCa) channels, increasing the potassium curren... |
